According to the coastal survey of Zhejiang Province from 2014 to 2016, the Uroteuthis edulis was selected as target species, using boosted regression tree(BRT) to determine the weight of different environmental factors, and also utilize the arithmetic mean model (AMM) and geometric mean model (GMM) to construct the multifactor habitat suitability index (HSI) model. The results showed that the suitable range of sea surface temperature (SST), sea surface salinity (SSS), chlorophyll-a (Chl.a) and dissolved oxygen (DO) in spring for U. edulis habitat area was 22-24℃, 34-36, 0.5-1.5 mg/m³, 8-10 mg/L, respectively; the suitable range of SST, SSS, Chl.a and DO in summer for U. edulis was 23-24℃, 31-34, 0.5-1.5 mg/m³ and 7-11 mg/L, respectively, little seasonal variation was observed; the results of BRT showed that SST was the most important environmental factor, and the other factors ranked as DO, Chl.a and DO, respectively. The spatiotemporal distribution U.edulis is:HSI in spring is relatively low, and occurred in the southern area (27°N-29°N); in summer, HSI is relatively high and often occurred in the northern area (30°N -31°N). Compared with two different algorithms, GMM had lower AIC value than that of AMM, so GMM is more suitable for the habitat suitability study of U. edulis. The optimal habitat distribution of U. edulis in the coast of Zhejiang Province is closely related with some factors, such as the oceanographic variation and current change.