The pretreatment-ultrafiltration-reverse osmosis process was carried out in a pesticide enterprise to testify the operation performance. The results showed that COD_cr,TOC and the active ingredients of drugs removal efficiency were 98.90%,98.73% and 99% respectively, the water production rate was also more than 70%, which illustrated that this process was successful, and operated stably and reliably with high treatment efficiency. The water quality of effluent could meet the enterprise's internal control standard and this process had remarkable economic benefits and broad application prospect.