By method of polyarylamide gel electrophoresis, effect of cadmium on the patterns of three isozymes (LDH,POD and SOD) in blood cells of Boleophthalmus pectinirostris was revealed for the first time. The results showed that all the three concentration groups indicate differential patterns of the LDH,POD and SOD isozymes in the situation of acute toxicosis. And the activities of three isozymes showed significant variety. The influence of cadmium on the expression of isozymes in blood cells of Boleophthalmus pectinirostris and the feasibility of using isozymes markers as marine ecotoxicology indicators were discussed.