This paper reports the research results of pathology of the hepatopancreas of Penaeus chinensis caused by brokenthrough viral disease in Shanghai area. Histopathological changes: The pathological changes in hepatopancreas were mainly characterised by the diffuse necrosis and two kinds of virion and two types of ball - shaped occlusion bodies positively stained by Feulgen Reagent were found in epithelial cell nucleus. Biochemical changes: The relatively decreased activities of EST and SOD in the hepatopancreas of diseased shrimp were indicated that the function of metabolism and immunization decreased significantly by the viral disease.