To investigate the optimal fishmeal and fish oil replacement levels in grow-out stage snakehead （initial body mass 150 g）， Channa striata， we first explored the optimal fishmeal replacement level by substituting 0%， 17%， 33%， 50%， 67%， and 83% of fishmeal 65 （65%-protein fishmeal） with poultry meal respectively， resulting in six iso-nitrogenous and iso-lipidic experimental diets. The diets were fed to fish to apparent satiation twice daily for 8 weeks. Subsequently， we evaluated the optimal level of fish oil substitution by replacing 0%， 13%， 25%， 38%， 50%， and 63% of fish oil with soy lecithin， resulting in six iso-nitrogenous and iso-lipidic experimental diets. The diets were also fed to fish to apparent satiation twice daily for 8 weeks.Results showed replacing fishmeal 65 with poultry meal had no significant effects on the growth performance， body indices， nutrient apparent digestibility， or body composition of snakehead fish （P>0.05）. Substituting fish oil with soy lecithin did not significantly influence the growth performance， body indices， or body composition of the fish （P>0.05）， nor did it affect the apparent digestibility of dry matter and crude protein （P>0.05）； however， a minor significant reduction in the apparent digestibility of crude lipids （~2%） was observed when fish oil substitution levels reached or exceeded 38% （P<0.05）.Results on growth， feed utilization， and body composition indicate that poultry meal can replace up to 83% of fishmeal 65 and soy lecithin up to 63% of fish oil in diets for grow-out stage snakehead.This study fills the research gap in the substitution of fishmeal and fish oil during the grow-out phase of Channa striata， offering valuable data for optimizing commercial feed composition and reducing costs.