To establish a rat cardiovascular thrombosis model and to observe the fibrinolytic properties of the marine bisindole alkaloid FGFC1 (Fungi Fibrinolytic Compound 1) in dissolving rat cardiovascular thrombus, a rat cardiovascular thrombosis model was established using fluorescein 5-isothiocyanate (FITC)-labeled fibrin induction method. Myocardial tissue morphology was imaged by low-field NMR, fluorescence scanning of frozen sections and hematoxylin-eosin staining (HE) of paraffin sections. Plasma fluorescence intensity was measured in the blank group, control group, u-PA positive control group and FGFC1 low, medium and high dose groups., and plasma fibrin degradation product (FDP), D-dimer (D-D) and plasminogen (Plg) were measured by ELISA. FITC-FIB was successfully labeled as FITC-α, FITC-β, FITC-γ peptide chains by reduced SDS-PAGE, and the FITC-fibrin showed green fluorescence under fluorescence microscopy. Low-field NMR imaging showed increased density of cardiac tissue in the modeling group, and fluorescence scanning of frozen sections showed the presence of fluorescent material plaques in cardiac vessels, indicating the establishment of a cardiovascular thrombosis model, while HE staining of tissue sections showed abnormal myocardial fibers in the modeling group. activity levels were significantly lower than those of the blank group, and FDP levels and D-D levels were significantly higher than those of the blank group. FITC-fibrin induced the formation of cardiovascular thrombosis model in rats, and the marine bisindole alkaloid FGFC1 could reduce the Plg activity and promote the degradation of thrombus fibrin in rats.