In order to understand the distribution characteristics of total arsenic content, water-soluble arsenic species, and fat-soluble total arsenic content in different edible tissues (gonads, hepatopancreas, body meat, leg meat, clamp meat) of Eriocheir sinensis,inductively coupled plasma mass spectrometry and high performance liquid chromatography-inductively coupled plasma mass spectrometry were used to analyze the content of total arsenic, water-soluble arsenic species and fat-soluble total arsenic in different edible tissues of Eriocheir sinensis. The results showed:that the average content of total arsenic in female crabs showed a trend of gonadal>hepatopancreas>body and leg meat>clamp meat, and there was a significant difference; the average content of total arsenic in male crabs showed a trend of hepatopancreas>body, leg meat>clamp meat and gonads, and there were significant differences; the total arsenic content of different edible tissues of female and male crabs gradually increases with the increase of body weight, and the total arsenic content in the adult gonads and hepatopancreas of Eriocheir sinensis in 8 provinces is at a relatively stable level. the percentage of the 6 water-soluble arsenic in muscle tissue is 83.3%-99.6%, and the percentage of the 6 water-soluble arsenic in gonad and hepatopancreas tissue is 18.8%-51.8%, there was a significant difference in the percentage of water-soluble arsenic in muscle tissue and gonad, hepatopancreas tissue.The percentage of total fat-soluble arsenic in the gonadal (female) and hepatopancreas (female, male) tissues ranged from 14.3% to 72.6%, and there was no significant difference in the average percentage of total fat-soluble arsenic in the three tissues. The total arsenic content in the fat of the three tissues was positively correlated with the total arsenic content of the corresponding tissues, but there was no positive correlation with the percentage of the corresponding tissue fat. It can be seen that there are differences in total arsenic content in different edible tissues of Eriocheir sinensis, water-soluble arsenic is the main form of arsenic in muscle tissue, and arsenic betaine (AsB) is the main component of water-soluble arsenic, there is a certain amount of fat-soluble arsenic in the gonadal (female) and hepatopancreas tissues, there are no reports on the types, metabolism, potential toxicity and sources of fat-soluble arsenic in Eriocheir sinensis.