Walleye pollock (Gadus chalcogrammus) is the most important commercial fish species in the waters through the Bering Sea to the North Pacific Ocean, and is the keystone species in the ecosystem of this region. Anisakis sp. is the common parasite in walleye pollock, particularly in the liver of this species. Therefore, In order to explore infection of Anisakis sp. to liver of walleye pollock and the factors that affect this process, this study analyzed infection of Anisakis sp. to liver of walleye pollock in the western Bering Sea and explained the factors that impact infection of Anisakis sp. to liver of walleye pollock using generalized linear model. The results indicated that the infection intensity was high and reached 93.3%, however, no significant difference could be observed in infection intensity of Anisakis sp. between sexes of host. The infection intensity of Anisakis sp. increased with the increasing of host size and eastern moving of sampling locations, but decreased with the lapse of time in a day. The study provides the scientific information about biology of walleye pollock and Anisakis sp. in the western Bering Sea and provides the basic data for food web structure in the North Pacific Ocean.