Foodborne diseases of aquatic products are one of the major public health and safety problems. It is very important to control the growth of pathogenic bacteria. The abuse of antibiotics leads to drug resistance of pathogens, so it is necessary to find another safe and effective method to replace antibiotics to inhibit pathogens in aquatic products. Bacteriophages have attracted much attention because of their ability to cleave pathogens and are considered to be the most promising biological bacteriostatic agent to replace antibiotics. Based on the introduction of the definition and mechanism of bacteriophage, the research progress of bacteriophage on Vibrio parahaemolyticus, Salmonella, Vibrio alginolyticus and Vibrio cholera was reviewed. The main problems and solutions in the application of bacteriophage were put forward and its future development prospect was also prospected so as to provide the theoretical reference for the research and application of bacteriophage in aquatic products.