We compared photos,wound healing rate, scar reduction rate, IL-6, IL-10, TGF-β, etc. in the skin wound healing process of the groups of IG low, medium and high dose enzymolysis products of oyster by animal experiment, and the results are shown as follows:The wound healing rate of the low and high dose groups was higher than that of the two control groups at 6 and 10 days and on the 14th day the healing rate of the low and high dose groups was significantly higher than that of the negative control group(P<0.05); Enzymolysis products of oyster can inhibit the production of inflammatory factor IL-6 and promote IL-10 secretion(P<0.05); The FGF-2 content in the low dose group was higher than the other groups but there was no significant difference (P>0.05), compared with the TGF-β content in the negative control group(P<0.05), the levels of CCND1 in the three dose groups were significantly higher than the two control groups (P>0.05), and the EGF content in the low and high dose groups was significantly higher than that in the other groups(P>0.05); On the 7th day the hydroxyproline content in the low dose group was significantly higher than that in the negative control group (P<0.05), and on the 14th day the hydroxyproline content in the skin tissue was significantly increased in each administration group and low dose group improves scar contraction rate (P<0.05).Enzymolysis products of oyster has accelerated wound healing of soft tissue in mice and has a certain inhibitory effect on superficial scar hyperplasia.