We studied the changes of Pseudosciaena crocea at the age of 8 months in growth and fatness along with the change of age which was fed in the low salinity (salinity of 5) conditions, indoor recirculating aquaculture and same age marine cage cultured (salinity of 35) Pseudosciaena crocea. The results show that the growth rate of weight of normal seawater salinity cage cultured large yellow croaker was significantly higher than that cultured in the desalination circulating water. And in two different culture conditions, the fatness of large yellow croaker fluctuates over time, and the degree of fatness in breeding season of large yellow croaker is higher than that in non-breeding season. The gonad of large yellow croaker which grew up in salinity of 5 seawater can develop to maturity, but the gonadosomatic index is lower than that of the one that grew up in normal seawater. Furthermore, the gonadal mature egg cell proportion of desalination group was significantly lower than that of normal seawater group of large yellow croaker. In general, this experiment laid the foundation for breeding and artificial propagation of large yellow croaker in desalination culture conditions.