Currently Litopenaeus vannamei play an important role in shrimp culture industry,greenhouse high-intensive ponds was an important farming method in Ningbo, Zhejiang. Research on stocking density and water quality control technology is imperative to promote the farming method.Through the first crop of 70 days breeding experiments we found that the result is good about using high density (315 ind/m², 375 ind/m²) breeding, the yields were 1.54 kg/m² and 1.32 kg/m², respectively. Significant difference was no observed on the effects of the growth and breeding of shrimp in the two level of breeding density, and then no significant difference was observed in the water quality indexes, NH₃-Nm(0.058-0.081 mg) and NO₂^--N(0.001-4.290 mg/L) were controlled in the normal range. Main water quality indexes was improved by changing the amount of water, controlling the feed, using aerator and probiotics. TAN and COD_Mn was significantly decreased 34.7% and 29.9%, when the quantity of exchanged water was reached 20%, and increased 11.8%-29.4% DO in using aerators 2 hours later. Seedling densities greater than 300 ind /m² are feasible in greenhouse high-intensive ponds, and water quality can be regulated by a simple control measures, this would promote greenhouse high-intensive ponds culturing Litopenaeus vannamei.