The key technologues of Brachymystax lenok tsinlingensis were studied on parent fish domestication, artificial breeding and hatching. The appropriate varieties and dosages of exogenous hormones were explored for promoting maturation and spawning of parent fish. 580 five-to-nine -year -old parental fish were primarily acquired in the wild from March 2011 to March 2014. The results showed that through a 30-day-domesticated feeding Tenebrio molitor, the wild parental fish was totally accustomed to artificial food. And according to the results, treating the fish with exogenous hormone DOM (2.5 mg/kg) and S-GnRHa (3μg/kg) would accelerate the maturation of the parent fish. 4.56×10⁴ eggs and 8×10⁴ eggs were harvested artificially in 2013 and 2014 respectively. The average hatching rate was 63%, and the fertilization rate was 82.5% in 2013. The average hatching rate was 62.5%, and the fertilization rate was 85.5% in 2014. The periods when the fish-fry floated during initial food intake and feed conversion are critical. Based on the gonad development, a postulate-"protecting in winter, propagating in spring, growing in summer, cultivating in autumn" was proposed for the improvement of the quality of sperms and eggs during the artificial cultivation. Artemia was the better choice as initial feed during the period of critical artificial cultivation. Feeding high protein diets would improve survival rate during the period of food conversion after the complete maturation of the digestive and immune systems of the juvenile fish.