To study the effects of different opening diets on Odontobutis potamophila larvae growth and body composition, four opening diets were selected and they were rotifers enhanced cultivated by Chlorella vulgaris; egg yolks, rotifers +small cladocerans and larval dedicated opening diets. We selected the most palatable opening diets through 15d of feeding experiments. Experiments show that rotifer enhanced and cultivated by Chlorella vulgaris was the most suitable opening diet, with an average body length of 8.759 mm, average weight of 0.050 3 g, the survival rate of 94%, the protein content of 21.65% and the fat content of 1.57%; followed by rotifers +small cladocerans group and egg yolks group. Larval dedicated opening diets is not suitable as a weaning food.