Trichodinosis is the general term of disease which results from Trichodina parasitic on surface, gills and other parts of aquatic animals, causing mechanical damage, bacterial and viral infection or other types of complications. Currently, international guided medication of Trichodinosis is rare in the reality because of effectiveness losses and such factors; and abuses of non-standard medication, lack of theoretical support, prevail. This paper comprehensively summarizes taxonomy, parasitic characteristics, epidemiological characteristics, and other basic theories and research situations of Trichodiniasis, and the current application situations of five international medicines, namely, the mixture copper sulphate and ferrisulphas, formalin, mebendazole, sodium chloride and four alkyl quaternary ammonium salt iodine complex. The paper systematically finishes reported chemistry, antibiotics and herbal medicine effectiveness and relevant safety research. In the author's opinion, Chinese herbal medicine is Chinese traditional treasure, and it is given attention because of its good effectiveness, low residues, non-drug resistance and little pollution. Chinese herbal medicine is still in the initial stage in the prevention and control of Trichinosis. The ongoing research directions are firstly; continually strengthen the basic theoretical research such as diagnosis of parasites, epidemiological investigation, putting forward ideas for screening medicines; secondly screening, more Chinese herbal medicine which can be applied in prevention and control of fish diseases; thirdly, discriminating of extraction, concentration, separation and structure identification of active medical substances to ensure medical safety; fourthly, doing research of combination and compound to improve medical effectiveness and immunity; fifthly, doing bionic model of high effectiveness, simple structure active substance to reduce cost of natural preparation.