Localization strategy is the key way for transnational enterprises to survive and develop in the wave of economic globalization. Human resources localization is the hinge of localization strategy. There are many driving forces for transnational enterprises to adopt human resources localization strategy. It can attract local talents to cut down managing cost, reduce culture friction to accelerate culture fusion, meet consumer demands to broaden marketing channels and ameliorate the relation with the country to promote corporate image. During the localization of human resources, transnational enterprises will meet with many difficult problems such as executing the values of parent company, promoting the sense of belonging of the local staffs, holding the level of human resources localization and winning the supports of host governments in talents attraction. Transnational enterprises must innovatively carry on the values of parent company, steadily push the process of human resources localization, jointly cultivate local talents in host countries and reasonably work out emolument systems to assure successful management all over the world.