Haematological biochemistry indices of Acipenser schrenckii cultured at different salinities(0,10,20,25,28) for 20 days respectively were measured.The results showed that the values of total protein(TP) increased first and then declined with the growth of the salinities.The values of T-BIL increased gradually with the addition of the salinities.The varieties of TRIG was consistent with that of the TP,the values of cholesterin(CHOL) had no significant variations with the increase of the salinities,and high density lipoprotein cholesterin(HDL-C) first decreased slowly then increased slightly with the enhancement of the salinities,and the values of blood glucose(G) first reduced then increased with the growth of the salinities.The values of CREA increased first and then declined,The values of BUN increased first and then declined.With the growth of the salinities,the values of alkaline phosphatase(ALP) declined gradually,and the values of amylase(AMY) first dropped then rose,and the values of aspartate aminotransferase(AST) first increased,then dropped and added in the end,which was similar to the varieties of the alanine aminotransferase(ALT).Na+ concentration first increased,then declined and kept stable finally,which was similar to the changes of Cl-and P,and K+ concentration first increased and then decreased,yet Ca2+ concentration had no significant changes.By analysing the haematological biochemistry indices after salinities domestication,Amur sturgeon possessed better osmoregulation abilities and could live in the 28 salt water after domestication.