With many kinds of important physiological actions, calcium is one of the most important nutrients and essential for human body. Calcium intaking deficiency will give to hypocalcia symptom or even more seriously calcium-malnutrition disease. The fine processing of surplus freshwater fish bone fully being utilized, calcium powder of fish bone can be made by heating, saponification and degrease, degumming and defishy. Biological utilgation and clinical trial show that the powder has good calcium absorbed and reserve dose rate,much better than common calcium powder in therapeutic effect. It is obviously that this is a new kind of high-quality natural calcium powder. The investigation in comprehensive utilization of freshwater fish processing has important significance.