To address the inefficient dewatering of solid waste in seawater aquaculture effluent （characterized by high moisture， viscosity， and fine particles）， a chamber filter press was designed based on the slurry's measured physicochemical properties. A multi-chamber CFD model was established in FLUENT to simulate the filtration process. Operational parameters were optimized using a Box-Behnken response surface methodology targeting filter cake moisture content. The optimal combination was 0.85 MPa feed pressure， 0.15 medium porosity， and 20% feed concentration， giving a predicted moisture content of 46.65%. Prototype tests yielded an average cake moisture content of 51.46%， with the filtrate containing 14.3 mg/L suspended solids at pH 7.55， meeting discharge standards. The study demonstrates that the chamber filter press， optimized through integrated CFD simulation and response surface methodology， achieves effective solid-liquid separation， providing a viable solution for the reduction and resource recovery of aquaculture solid waste.